Microbial transformation of bioactive natural products
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Date
2010
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Abstract
In the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity.
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Adhathoda vasica extract, alkaloid, chloramphenicol, ketoconazole, plant extract, unclassified drug, vasicine, vasicinone, Adhathoda vasica, antimicrobial activity, article, Aspergillus niger, biocatalysis, biotransformation, Candida albicans, controlled study, drug isolation, drug screening, Escherichia coli, fungal biotransformation, fungus, human, mass fragmentography, medicinal plant, outcome assessment, Pencillium notatum, proton nuclear magnetic resonance, Pseudomonas aeruginosa, Rhizopus, Staphylococcus aureus, thin layer chromatography, Trematus versicolor, Rhizopus oryzae, Tetra
Citation
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2010, 1, 3, pp. 826-831