Microbial transformation of bioactive natural products

Abstract

In the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity.