Rhodamine-based Cu2+-selective fluorosensor: Synthesis, mechanism, and application in living cells
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2013
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Abstract
A rhodamine B-based fluorescence probe (1) for the sensitive and selective detection of Cu2+ ion has been designed and synthesized using pyridine moiety. The optical properties of this compound have been investigated in acetonitrile-water binary solution (7:3 v/v). Compound 1 is found to be an excellent sensor for a biologically/physiologically very important transition metal ion (Cu2+) using only the two very different modes of measurements (absorption and emission); one case displayed intensity enhancement whereas in other case showed intensity depletion (quenching). A mechanistic investigation has been performed to explore the static nature of quenching process. The sensor has been found to be very effective in sensing Cu 2+ ion inside living cells also. © 2013 Springer Science+Business Media New York.
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Keywords
Absorption and emissions, Chemo-sensors, Fluorescence probes, Intensity enhancement, Living cell, Rhodamine B, Selective detection, Static quenching, Metal ions, Optical properties, Positive ions, Sensors, Synthesis (chemical), copper, fluorescent dye, rhodamine, rhodamine B, Schiff base, cell survival, chemical analysis, chemistry, cytology, devices, Escherichia coli, spectrofluorometry, synthesis, Cell Survival, Chemistry Techniques, Analytical, Chemistry Techniques, Synthetic, Copper, Fluorescent Dyes, Rhodamines, Schiff Bases, Spectrometry, Fluorescence
Citation
Journal of Fluorescence, 2013, 23, 3, pp. 495-501