Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents
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Date
2014
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Abstract
Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. © 2014 Elsevier Ltd. All rights reserved.
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Keywords
1,2,3 triazole derivative, 3 bromo 4 ethoxy 8 trifluoromethyl quinoline, 3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid, 3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid ester, 4 (1 benzyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 (1 butyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 (1 ethyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 (1 propyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 (2,4 dichlorobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 (4 nitrobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 [2 (4 bromophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 [2 (4 chlorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 [2 (4 fluorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 [1 [2 (4 methoxyphenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester, 4 ethoxy 3 (1 methyl 1h indol 5 yl) 8 triuoromethyl quinoline, antibiotic agent, antifungal agent, ciprofloxacin, fluconazole, unclassified drug, antibacterial activity, antifungal activity, article, Aspergillus flavus, Bacillus subtilis, Candida albicans, Chrysosporium keratinophilum, click chemistry, controlled study, drug potency, drug screening, drug synthesis, Escherichia coli, in vitro study, nonhuman, one pot synthesis, Pseudomonas aeruginosa, X ray analysis, 1,2,3-Triazole, 8-Trifluoromethylquinoline, Antimicrobial activity, Click chemistry, Suzuki coupling, Anti-Infective Agents, Click Chemistry, Magnetic Resonance Spectroscopy, Models, Molecular, Quinolines, Triazoles
Citation
European Journal of Medicinal Chemistry, 2014, 74, , pp. 324-332