Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents

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dc.contributor.authorGarudachari, B.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorSatyanarayana, M.N.
dc.contributor.authorFun, H.-K.
dc.contributor.authorHegde, G.
dc.date.accessioned2026-02-05T09:34:17Z
dc.date.issued2014
dc.description.abstractThree series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. © 2014 Elsevier Ltd. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2014, 74, , pp. 324-332
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2014.01.008
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26519
dc.subject1,2,3 triazole derivative
dc.subject3 bromo 4 ethoxy 8 trifluoromethyl quinoline
dc.subject3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid
dc.subject3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid ester
dc.subject4 (1 benzyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 (1 butyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 (1 ethyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 (1 propyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 (2,4 dichlorobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 (4 nitrobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 [2 (4 bromophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 [2 (4 chlorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 [2 (4 fluorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 [1 [2 (4 methoxyphenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester
dc.subject4 ethoxy 3 (1 methyl 1h indol 5 yl) 8 triuoromethyl quinoline
dc.subjectantibiotic agent
dc.subjectantifungal agent
dc.subjectciprofloxacin
dc.subjectfluconazole
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectarticle
dc.subjectAspergillus flavus
dc.subjectBacillus subtilis
dc.subjectCandida albicans
dc.subjectChrysosporium keratinophilum
dc.subjectclick chemistry
dc.subjectcontrolled study
dc.subjectdrug potency
dc.subjectdrug screening
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectin vitro study
dc.subjectnonhuman
dc.subjectone pot synthesis
dc.subjectPseudomonas aeruginosa
dc.subjectX ray analysis
dc.subject1,2,3-Triazole
dc.subject8-Trifluoromethylquinoline
dc.subjectAntimicrobial activity
dc.subjectClick chemistry
dc.subjectSuzuki coupling
dc.subjectAnti-Infective Agents
dc.subjectClick Chemistry
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectModels, Molecular
dc.subjectQuinolines
dc.subjectTriazoles
dc.titleClick chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents

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