Novel Indole-Quinazolinone Based Amides as Cytotoxic Agents
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Date
2016
Journal Title
Journal ISSN
Volume Title
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HeteroCorporation support@jhetchem.com
Abstract
Indole-quinazolinone hybrids with active amides were synthesized, characterized, and assessed for their cytotoxicity. Two molecules displayed substantial activity in sulphorhodamine B assay method. © 2015 HeteroCorporation.
Description
Keywords
1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid, 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamide, 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n [4 (trifluoromethoxy)phenyl] 1h indole 2 carboxamide, 1 methyl n (2 morpholinoethyl) 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, 2 (1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one, 2 (5 fluoro 1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one, 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid, 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamide, amide, antimitotic agent, cytotoxic agent, ethyl 1 methyl 1h indole 2 carboxylate, ethyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylate, ethyl 3 formyl 1 methyl 1h indole 2 carboxylate, ethyl 5 fluoro 1 methyl 1h indole 2 carboxylate, ethyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylate, ethyl 5 fluoro 3 formyl 1 methyl 1h indole 2 carboxylate, indole derivative, n (3,4 difluorophenyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (4 fluorobenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (4 fluorobenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydoquinazolin 2 yl) 1h indole 2 carboxamide, n (4 methoxybenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (4 methoxybenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (cyclohexylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (cyclopropylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n (cyclopropylmethyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n cyclopropyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, n cyclopropyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide, quinazolinone derivative, unclassified drug, unindexed drug, animal cell, antiproliferative activity, apoptosis, Article, cell cycle regulation, cell cycle S phase, controlled study, cytotoxicity, drug design, drug screening, drug synthesis, enzyme activity, enzyme inhibition, HepG2 cell line, human, human cell, in vitro study, MCF 7 cell line, melanoma cell line, nonhuman, Vero cell line
Citation
Journal of Heterocyclic Chemistry, 2016, 53, 2, pp. 513-524