Novel Indole-Quinazolinone Based Amides as Cytotoxic Agents

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dc.contributor.authorGokhale, N.
dc.contributor.authorPanathur, N.
dc.contributor.authorUdayakumar, D.
dc.contributor.authorNayak, P.G.
dc.contributor.authorPai, K.S.R.
dc.date.accessioned2026-02-05T09:33:16Z
dc.date.issued2016
dc.description.abstractIndole-quinazolinone hybrids with active amides were synthesized, characterized, and assessed for their cytotoxicity. Two molecules displayed substantial activity in sulphorhodamine B assay method. © 2015 HeteroCorporation.
dc.identifier.citationJournal of Heterocyclic Chemistry, 2016, 53, 2, pp. 513-524
dc.identifier.issn0022152X
dc.identifier.urihttps://doi.org/10.1002/jhet.2403
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26058
dc.publisherHeteroCorporation support@jhetchem.com
dc.subject1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid
dc.subject1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamide
dc.subject1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n [4 (trifluoromethoxy)phenyl] 1h indole 2 carboxamide
dc.subject1 methyl n (2 morpholinoethyl) 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subject2 (1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one
dc.subject2 (5 fluoro 1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one
dc.subject5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid
dc.subject5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamide
dc.subjectamide
dc.subjectantimitotic agent
dc.subjectcytotoxic agent
dc.subjectethyl 1 methyl 1h indole 2 carboxylate
dc.subjectethyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylate
dc.subjectethyl 3 formyl 1 methyl 1h indole 2 carboxylate
dc.subjectethyl 5 fluoro 1 methyl 1h indole 2 carboxylate
dc.subjectethyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylate
dc.subjectethyl 5 fluoro 3 formyl 1 methyl 1h indole 2 carboxylate
dc.subjectindole derivative
dc.subjectn (3,4 difluorophenyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (4 fluorobenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (4 fluorobenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydoquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (4 methoxybenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (4 methoxybenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (cyclohexylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (cyclopropylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn (cyclopropylmethyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn cyclopropyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectn cyclopropyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide
dc.subjectquinazolinone derivative
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectanimal cell
dc.subjectantiproliferative activity
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcell cycle regulation
dc.subjectcell cycle S phase
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectdrug design
dc.subjectdrug screening
dc.subjectdrug synthesis
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectHepG2 cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectMCF 7 cell line
dc.subjectmelanoma cell line
dc.subjectnonhuman
dc.subjectVero cell line
dc.titleNovel Indole-Quinazolinone Based Amides as Cytotoxic Agents

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