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Title: 1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies
Authors: Harikrishna, N.
Isloor, A.M.
Ananda, K.
Obaid, A.
Fun, H.-K.
Issue Date: 2015
Citation: RSC Advances, 2015, Vol.5, 54, pp.43648-43659
Abstract: A new series 3-{2-[N?-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 ?g ml-1 for a few of the synthesized compounds. The Royal Society of Chemistry 2015.
URI: 10.1039/c5ra04995d
Appears in Collections:1. Journal Articles

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