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Title: Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
Authors: Ubaradka, S.R.
Isloor, A.M.
Shetty, P.
Shetty, P.
Isloor, N.A.
Issue Date: 2013
Citation: Medicinal Chemistry Research, 2013, Vol.22, 3, pp.1497-1503
Abstract: In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. 2012 Springer Science+Business Media, LLC.
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