Please use this identifier to cite or link to this item:
Title: Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles
Authors: Isloor, A.M.
Kalluraya, B.
Shetty, P.
Issue Date: 2009
Citation: European Journal of Medicinal Chemistry, 2009, Vol.44, 9, pp.3784-3787
Abstract: In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, 1H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity. 2009 Elsevier Masson SAS. All rights reserved.
Appears in Collections:1. Journal Articles

Files in This Item:
File Description SizeFormat 
12778.pdf129.86 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.