Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/10981
Title: Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents
Authors: Eswaran, S.
Adhikari, A.V.
Pal, N.K.
Chowdhury, I.H.
Issue Date: 2010
Citation: Bioorganic and Medicinal Chemistry Letters, 2010, Vol.20, 3, pp.1040-1044
Abstract: A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis. 2009 Elsevier Ltd. All rights reserved.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/10981
Appears in Collections:1. Journal Articles

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