Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/10978
Title: Design and Synthesis of New Amides and Thioamides Derived from 3,4-Ethylenedioxythiophene as Potential Anticonvulsants
Authors: Kulandasamy, R.
Adhikari, A.V.
Stables, J.P.
Issue Date: 2010
Citation: Bulletin of the Korean Chemical Society, 2010, Vol.31, 11, pp.3318-3326
Abstract: Five new series of 3,4-ethylenedioxythiophene derivatives carrying important pharamacophores, viz., amide, ester, ether and active secondary aryl moieties have been designed and synthesized through multistep reactions starting from thiodiglycolic ester and diethyl oxalate. They have been characterized by elemental and spectral data. All the target compounds have been screened for their anticonvulsant activity at three different models viz. maximal electroshock (MES), subcutaneous metrazole (scMET), and 6 Hz screen and evaluated for their neurotoxicity in rotorod model. Compound 6a emerged as lead with no neurotoxicity. All the five series of compounds are safe in the toxicity studies at the maximum dose of 300 mg/kg of body weight. Amongst the tested compounds, the ester pharmacophore with thioamide fragment has showed better activity than the other analogs.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/10978
Appears in Collections:1. Journal Articles

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