An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

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dc.contributor.authorBhat, S.I.
dc.contributor.authorDas, U.K.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2026-02-05T09:33:41Z
dc.date.issued2015
dc.description.abstractAn efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.
dc.identifier.citationJournal of Heterocyclic Chemistry, 2015, 52, 4, pp. 1253-1259
dc.identifier.issn0022152X
dc.identifier.urihttps://doi.org/10.1002/jhet.2220
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26261
dc.publisherHeteroCorporation support@jhetchem.com
dc.subject2 aminoaryl ketone
dc.subject2 butyl 6 nitro 4 phenylquinazoline
dc.subject2 ethyl 6 nitro 4 phenylquinazoline
dc.subject2,4 diphenylquinazoline
dc.subject4 methyl 2 phenylquinazoline
dc.subject6 chloro 2,4 diphenylquinazoline
dc.subject6 chloro 4 (2 fluorophenyl) 2 methylquinazoline
dc.subject6,7 dimethoxy 2,4 dimethylquinazoline
dc.subjectammonium acetate
dc.subjectketone derivative
dc.subjectquinazoline derivative
dc.subjectsolvent
dc.subjectunclassified drug
dc.subjectaromatization
dc.subjectArticle
dc.subjectcatalyst
dc.subjectcyclization
dc.subjectdrug synthesis
dc.subjectelectron
dc.subjectgreen chemistry
dc.subjectone pot synthesis
dc.subjectreaction analysis
dc.subjectreaction time
dc.subjectspectroscopy
dc.subjectthin layer chromatography
dc.subjectX ray analysis
dc.subjectX ray diffraction
dc.titleAn Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

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