An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
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Date
2015
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HeteroCorporation support@jhetchem.com
Abstract
An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.
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Keywords
2 aminoaryl ketone, 2 butyl 6 nitro 4 phenylquinazoline, 2 ethyl 6 nitro 4 phenylquinazoline, 2,4 diphenylquinazoline, 4 methyl 2 phenylquinazoline, 6 chloro 2,4 diphenylquinazoline, 6 chloro 4 (2 fluorophenyl) 2 methylquinazoline, 6,7 dimethoxy 2,4 dimethylquinazoline, ammonium acetate, ketone derivative, quinazoline derivative, solvent, unclassified drug, aromatization, Article, catalyst, cyclization, drug synthesis, electron, green chemistry, one pot synthesis, reaction analysis, reaction time, spectroscopy, thin layer chromatography, X ray analysis, X ray diffraction
Citation
Journal of Heterocyclic Chemistry, 2015, 52, 4, pp. 1253-1259