Selective chromogenic nanomolar level sensing of arsenite anions in food samples using dual binding site probes

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dc.contributor.authorK, K.
dc.contributor.authorNityananda Shetty, A.N.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2026-02-03T13:20:18Z
dc.date.issued2025
dc.description.abstractIn the present study, two chromogenic probes, N7R2 and N7R3, each containing two binding sites, were designed and synthesized for the selective detection of arsenite in DMSO/H<inf>2</inf>O (1:1, v/v). The probes exhibited stability across a pH range spanning from 5 to 12. The lower detection limits of 2.01 ppb (18.86 nM) for N7R2 and 1.79 ppb (16.75 nM) for N7R3, which are much lower than the WHO recommended permissible limit of arsenite, confirmed the superior efficiency of the probes in detecting arsenite. The detection mechanism for arsenite was proposed through UV and 1H NMR titrations, electrochemical studies, and DFT calculations. Practical applications were demonstrated through the fabrication of test strips and molecular logic gates. The probes efficiently recognized arsenite in real water, honey, milk samples, and fruit/vegetable juices. Both N7R2 and N7R3 exhibited excellent recovery rates in the analysis of food samples, demonstrating the probes' usefulness in real sample analysis. © 2024
dc.identifier.citationFood Chemistry, 2025, 463, , pp. -
dc.identifier.issn3088146
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2024.141461
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/20467
dc.publisherElsevier Ltd
dc.subjectBinding sites
dc.subjectTitration
dc.subjectArsenite
dc.subjectBinding-sites
dc.subjectChromogenic probes
dc.subjectColorimetric sensors
dc.subjectDFT
dc.subjectFood samples
dc.subjectIntra-molecular charge transfer
dc.subjectIntramolecular charge transfers
dc.subjectLevel sensing
dc.subjectNanomolar levels
dc.subjectFruit juices
dc.subjectanion
dc.subjectarsenic acid
dc.subjectarsenic trioxide
dc.subjectdimethyl sulfoxide
dc.subjectfluorescent dye
dc.subjectn7r2
dc.subjectn7r3
dc.subjectriver water
dc.subjectsea water
dc.subjecttap water
dc.subjectunclassified drug
dc.subjectabsorption spectroscopy
dc.subjectapple juice
dc.subjectArticle
dc.subjectassociation constant
dc.subjectbinding competition
dc.subjectbinding site
dc.subjectcolorimetry
dc.subjectcomplex formation
dc.subjectcucumber
dc.subjectcyclic voltammetry
dc.subjectdensity functional theory
dc.subjectdeprotonation
dc.subjectdipole
dc.subjectelectrochemical analysis
dc.subjectelectron transport
dc.subjectelectrophilicity
dc.subjectfood
dc.subjectFourier transform infrared spectroscopy
dc.subjectfruit and vegetable juice
dc.subjecthoney
dc.subjecthydration
dc.subjecthydrogen bond
dc.subjectionization
dc.subjectlimit of detection
dc.subjectmaximum permissible dose
dc.subjectmilk
dc.subjectpH
dc.subjectplatinum electrode
dc.subjectpotato
dc.subjectproton nuclear magnetic resonance
dc.subjecttitrimetry
dc.subjecttomato juice
dc.subjectultraviolet visible spectroscopy
dc.subjectwater content
dc.subjectwater sampling
dc.subjectanimal
dc.subjectchemistry
dc.subjectfood contamination
dc.subjectAnimals
dc.subjectAnions
dc.subjectArsenites
dc.subjectBinding Sites
dc.subjectFood Contamination
dc.subjectFruit and Vegetable Juices
dc.subjectHoney
dc.subjectLimit of Detection
dc.subjectMilk
dc.titleSelective chromogenic nanomolar level sensing of arsenite anions in food samples using dual binding site probes

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