Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

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dc.contributor.authorMishra, R.
dc.contributor.authorKrishnamoorthy, P.
dc.contributor.authorGangamma, S.
dc.contributor.authorRaut, A.A.
dc.contributor.authorKumar, H.
dc.date.accessioned2026-02-05T09:28:01Z
dc.date.issued2020
dc.description.abstractParticulate matter (PM<inf>10</inf>) enhances severity of influenza virus infection through skewing innate immunity via modulation of metabolic pathways-related genes.; Sensing of pathogens by specialized receptors is the hallmark of the innate immunity. Innate immune response also mounts a defense response against various allergens and pollutants including particulate matter present in the atmosphere. Air pollution has been included as the top threat to global health declared by WHO which aims to cover more than three billion people against health emergencies from 2019 to 2023. Particulate matter (PM), one of the major components of air pollution, is a significant risk factor for many human diseases and its adverse effects include morbidity and premature deaths throughout the world. Several clinical and epidemiological studies have identified a key link between the PM existence and the prevalence of respiratory and inflammatory disorders. However, the underlying molecular mechanism is not well understood. Here, we investigated the influence of air pollutant, PM<inf>10</inf> (particles with aerodynamic diameter less than 10 ?m) during RNA virus infections using Highly Pathogenic Avian Influenza (HPAI) – H5N1 virus. We thus characterized the transcriptomic profile of lung epithelial cell line, A549 treated with PM<inf>10</inf> prior to H5N1infection, which is known to cause severe lung damage and respiratory disease. We found that PM<inf>10</inf> enhances vulnerability (by cellular damage) and regulates virus infectivity to enhance overall pathogenic burden in the lung cells. Additionally, the transcriptomic profile highlights the connection of host factors related to various metabolic pathways and immune responses which were dysregulated during virus infection. Collectively, our findings suggest a strong link between the prevalence of respiratory illness and its association with the air quality. © 2020 Elsevier Ltd; © 2020 Elsevier Ltd
dc.identifier.citationEnvironmental Pollution, 2020, 266, , pp. -
dc.identifier.issn2697491
dc.identifier.urihttps://doi.org/10.1016/j.envpol.2020.115148
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/23643
dc.publisherElsevier Ltd
dc.subjectAir quality
dc.subjectBiological organs
dc.subjectCell culture
dc.subjectDiseases
dc.subjectHealth risks
dc.subjectImmune system
dc.subjectMetabolism
dc.subjectModulation
dc.subjectRNA
dc.subjectViruses
dc.subjectAerodynamic diameters
dc.subjectEpidemiological studies
dc.subjectHighly pathogenic avian influenzas
dc.subjectInflammatory disorders
dc.subjectInnate immune response
dc.subjectLung epithelial cells
dc.subjectMolecular mechanism
dc.subjectRespiratory illness
dc.subjectParticles (particulate matter)
dc.subjectair quality
dc.subjectatmospheric pollution
dc.subjectcell
dc.subjectepidemiology
dc.subjectimmune response
dc.subjectinfectious disease
dc.subjectinnate behavior
dc.subjectmetabolism
dc.subjectparticulate matter
dc.subjectpathogen
dc.subjectrisk factor
dc.subjectviral disease
dc.subjectaerodynamic diameter
dc.subjectair pollution
dc.subjectArticle
dc.subjectavian influenza (H5N1)
dc.subjectcontrolled study
dc.subjectenergy dispersive X ray spectroscopy
dc.subjecthuman
dc.subjecthuman cell
dc.subjectInfluenza A virus (H5N1)
dc.subjectinnate immunity
dc.subjectlimit of quantitation
dc.subjectlung injury
dc.subjectmorbidity
dc.subjectnonhuman
dc.subjectparticle size
dc.subjectphysical parameters
dc.subjectprevalence
dc.subjectreal time reverse transcription polymerase chain reaction
dc.subjectrespiratory tract disease
dc.subjectscanning electron microscopy
dc.subjecttranscriptomics
dc.subjectvirus load
dc.subjectvirus replication
dc.subjectvirus strain
dc.subjectWorld Health Organization
dc.subjectair pollutant
dc.subjectanimal
dc.subjectRNA virus infection
dc.subjectOrthomyxoviridae
dc.subjectRNA viruses
dc.subjectAir Pollutants
dc.subjectAir Pollution
dc.subjectAnimals
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectInfluenza A Virus, H5N1 Subtype
dc.subjectParticulate Matter
dc.subjectRNA Virus Infections
dc.titleParticulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

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