Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles

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dc.contributor.authorUbaradka, S.R.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorShetty, P.
dc.contributor.authorShetty, P.
dc.contributor.authorIsloor, N.A.
dc.date.accessioned2026-02-05T09:34:53Z
dc.date.issued2013
dc.description.abstractIn this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. © 2012 Springer Science+Business Media, LLC.
dc.identifier.citationMedicinal Chemistry Research, 2013, 22, 3, pp. 1497-1503
dc.identifier.issn10542523
dc.identifier.urihttps://doi.org/10.1007/s00044-012-0103-1
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26823
dc.subject1,2,4 oxadiazole derivative
dc.subject3,4 dihydro 3 [5 (thiazol 2 yl) 1,2,4 oxadiazol 3 yl] n [(thiazol 2 yl)methylene] 2h chromen 2 amine
dc.subject3,4 dihydro 3 [5 (thiophen 2 yl) 1,2,4 oxadiaozl 3 yl] n [(thiophen 2 yl)methylene] 2h chromen 2 amine
dc.subject3,4 dihydro n (3 phenylallylidene) 3 (5 styryl 1,2,4 oxadiazol 3 yl) 2h chromen 2 amine
dc.subjectaldehyde derivative
dc.subjectamidine
dc.subjectanticonvulsive agent
dc.subjectantiinflammatory agent
dc.subjectchromene derivative
dc.subjectdiazepam
dc.subjectdiclofenac
dc.subjectn (2 hydroxybenzylidene) 3 [5 (2 hydroxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (3 nitrobenzylidene) 3,4 diihydro 3 [5 (3 nitrophenyl) 1,2,4 oxadiazol 3 yl] 2h chromen 2 amine
dc.subjectn (3,4 dimethoxybenzylidene) 3,4 dihydro 3 [5 (3,4 dimethoxyphenyl) 1,2,4 oxadiazol 3 yl] 2 h chromen 2 amine
dc.subjectn (4 bromobenzylidene) 3 [5 (4 bromophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (4 chlorobenzylidene) 3 [5 (4 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (4 fluoro 3 phenoxybenzylidene) 3 [5 (4 fluoro 3 phenoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (4 fluorobenzylidene) 3 [5 (4 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (4 hydroxy 3 methoxybenzylidene) 3 [5 (4 hydroxy 3 methoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn (5 bromo 2 fluorobenzylidene) 3 [5 (5 bromo 2 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectn benzylidene 3,4 dihdyro 3 (5 phenyl 1,2,4 oxadiazol 3 yl) 2h chromen 2 amine
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanticonvulsant activity
dc.subjectantiinflammatory activity
dc.subjectarticle
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectdrug screening
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectmale
dc.subjectmicrowave irradiation
dc.subjectmouse
dc.subjectn (2 chlorobenzylidene) 3 [5 (2 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine
dc.subjectnitrogen nuclear magnetic resonance
dc.subjectnonhuman
dc.subjectpaw edema
dc.subjectproton nuclear magnetic resonance
dc.subjectrat
dc.subjectstructure analysis
dc.subjecttonic clonic seizure
dc.titleSynthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles

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