Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
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Date
2013
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Abstract
In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. © 2012 Springer Science+Business Media, LLC.
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1,2,4 oxadiazole derivative, 3,4 dihydro 3 [5 (thiazol 2 yl) 1,2,4 oxadiazol 3 yl] n [(thiazol 2 yl)methylene] 2h chromen 2 amine, 3,4 dihydro 3 [5 (thiophen 2 yl) 1,2,4 oxadiaozl 3 yl] n [(thiophen 2 yl)methylene] 2h chromen 2 amine, 3,4 dihydro n (3 phenylallylidene) 3 (5 styryl 1,2,4 oxadiazol 3 yl) 2h chromen 2 amine, aldehyde derivative, amidine, anticonvulsive agent, antiinflammatory agent, chromene derivative, diazepam, diclofenac, n (2 hydroxybenzylidene) 3 [5 (2 hydroxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (3 nitrobenzylidene) 3,4 diihydro 3 [5 (3 nitrophenyl) 1,2,4 oxadiazol 3 yl] 2h chromen 2 amine, n (3,4 dimethoxybenzylidene) 3,4 dihydro 3 [5 (3,4 dimethoxyphenyl) 1,2,4 oxadiazol 3 yl] 2 h chromen 2 amine, n (4 bromobenzylidene) 3 [5 (4 bromophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (4 chlorobenzylidene) 3 [5 (4 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (4 fluoro 3 phenoxybenzylidene) 3 [5 (4 fluoro 3 phenoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (4 fluorobenzylidene) 3 [5 (4 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (4 hydroxy 3 methoxybenzylidene) 3 [5 (4 hydroxy 3 methoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n (5 bromo 2 fluorobenzylidene) 3 [5 (5 bromo 2 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, n benzylidene 3,4 dihdyro 3 (5 phenyl 1,2,4 oxadiazol 3 yl) 2h chromen 2 amine, unclassified drug, animal experiment, animal model, anticonvulsant activity, antiinflammatory activity, article, carbon nuclear magnetic resonance, controlled study, drug screening, drug structure, drug synthesis, male, microwave irradiation, mouse, n (2 chlorobenzylidene) 3 [5 (2 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 amine, nitrogen nuclear magnetic resonance, nonhuman, paw edema, proton nuclear magnetic resonance, rat, structure analysis, tonic clonic seizure
Citation
Medicinal Chemistry Research, 2013, 22, 3, pp. 1497-1503