Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

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dc.contributor.authorEswaran, S.
dc.contributor.authorVasudeva Adhikari, A.V.
dc.contributor.authorPal, N.K.
dc.contributor.authorChowdhury, I.H.
dc.date.accessioned2026-02-05T09:36:27Z
dc.date.issued2010
dc.description.abstractA series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis. © 2009 Elsevier Ltd. All rights reserved.
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, 2010, 20, 3, pp. 1040-1044
dc.identifier.issn0960894X
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2009.12.045
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27504
dc.publisherElsevier Ltd
dc.subjectantimycobacterial agent
dc.subjectisoniazid
dc.subjectquinoline 3 carbohydrazone derivative
dc.subjectquinoline derivative
dc.subjectrifampicin
dc.subjectunclassified drug
dc.subjectantiinfective agent
dc.subjecthydrazone derivative
dc.subjectantibacterial activity
dc.subjectarticle
dc.subjectbroth dilution
dc.subjectcontrolled study
dc.subjectdrug design
dc.subjectdrug efficacy
dc.subjectdrug synthesis
dc.subjectin vitro study
dc.subjectminimum inhibitory concentration
dc.subjectMycobacterium fortuitum
dc.subjectMycobacterium smegmatis
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectpharmacophore
dc.subjectcomparative study
dc.subjectdrug effects
dc.subjectMycobacterium
dc.subjectphysiology
dc.subjectsynthesis
dc.subjectAnti-Bacterial Agents
dc.subjectDrug Design
dc.subjectHydrazones
dc.subjectQuinolines
dc.titleDesign and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

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