Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Abstract
A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis. © 2009 Elsevier Ltd. All rights reserved.
Description
Keywords
antimycobacterial agent, isoniazid, quinoline 3 carbohydrazone derivative, quinoline derivative, rifampicin, unclassified drug, antiinfective agent, hydrazone derivative, antibacterial activity, article, broth dilution, controlled study, drug design, drug efficacy, drug synthesis, in vitro study, minimum inhibitory concentration, Mycobacterium fortuitum, Mycobacterium smegmatis, Mycobacterium tuberculosis, nonhuman, pharmacophore, comparative study, drug effects, Mycobacterium, physiology, synthesis, Anti-Bacterial Agents, Drug Design, Hydrazones, Quinolines
Citation
Bioorganic and Medicinal Chemistry Letters, 2010, 20, 3, pp. 1040-1044