Synthesis, and antitubercular and antimicrobial activity of 1?-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives

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dc.contributor.authorHarikrishna, N.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorKulal, K.
dc.contributor.authorAlObaid, A.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:33:29Z
dc.date.issued2016
dc.description.abstractA new series of 1?-(4-chlorophenyl)-5-(substituted aryl)-3?-(substituted aryl)-3,4-dihydro-2H,1?H-[3,4?]bipyrazolyl derivatives (6a-e, 8a-e, 10a-e) have been synthesized, characterized and screened for antimicrobial and antitubercular activity. Among the synthesized compounds, the minimum inhibition concentration of 10e was found to be as low as 1.56 ?g ml-1 and that of 10c was 6.25 ?g ml-1 as compared to the standard anti-tb drugs pyrazinamide and streptomycin. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.
dc.identifier.citationNew Journal of Chemistry, 2016, 40, 1, pp. 73-76
dc.identifier.issn11440546
dc.identifier.urihttps://doi.org/10.1039/c5nj02237a
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26163
dc.publisherRoyal Society of Chemistry
dc.subject1' (4 chlorophenyl) 5 (2,3 dihydrobenzofuran 5 yl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl
dc.subject1' (4 chlorophenyl) 5 (5 methylfuran 2 yl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl
dc.subject5 biphenyl 4 yl 1' (4 chlorophenyl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl
dc.subjectantiinfective agent
dc.subjectpyrazinamide
dc.subjectpyrazoline derivative
dc.subjectstreptomycin
dc.subjecttuberculostatic agent
dc.subjectunclassified drug
dc.subjectantimicrobial activity
dc.subjectantitubercular activity
dc.subjectArticle
dc.subjectcarbon nuclear magnetic resonance
dc.subjectdrug activity
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectminimum inhibitory concentration
dc.subjectpriority journal
dc.subjectproton nuclear magnetic resonance
dc.titleSynthesis, and antitubercular and antimicrobial activity of 1?-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives

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