Synthesis, and antitubercular and antimicrobial activity of 1?-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
A new series of 1?-(4-chlorophenyl)-5-(substituted aryl)-3?-(substituted aryl)-3,4-dihydro-2H,1?H-[3,4?]bipyrazolyl derivatives (6a-e, 8a-e, 10a-e) have been synthesized, characterized and screened for antimicrobial and antitubercular activity. Among the synthesized compounds, the minimum inhibition concentration of 10e was found to be as low as 1.56 ?g ml-1 and that of 10c was 6.25 ?g ml-1 as compared to the standard anti-tb drugs pyrazinamide and streptomycin. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.
Description
Keywords
1' (4 chlorophenyl) 5 (2,3 dihydrobenzofuran 5 yl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl, 1' (4 chlorophenyl) 5 (5 methylfuran 2 yl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl, 5 biphenyl 4 yl 1' (4 chlorophenyl) 3' phenyl 3,4 dihydro 2h,1h [3,4']bipyrazolyl, antiinfective agent, pyrazinamide, pyrazoline derivative, streptomycin, tuberculostatic agent, unclassified drug, antimicrobial activity, antitubercular activity, Article, carbon nuclear magnetic resonance, drug activity, drug structure, drug synthesis, minimum inhibitory concentration, priority journal, proton nuclear magnetic resonance
Citation
New Journal of Chemistry, 2016, 40, 1, pp. 73-76