Synthesis and evaluation of antioxidant, antimicrobial activities of new 2,4-disubstituted thiazoles
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Date
2012
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Abstract
A new series of 2,4-disubstituted thiazole derivatives were synthesized by the reaction of various 3-aryl-1H-pyrazole-4- carbaldehyde thiosemicarbazones (2a-e) and phenacyl bromides. The compounds (3a-n) were characterized by IR, NMR, mass spectra and C, H, N analyses. All the synthesized compounds were screened for their antioxidant and antimicrobial activities. Antioxidant studies revealed that, compounds 3b, 3j and 3n showed significant scavenging activity whereas compounds 3e and 3n exhibited significant antimicrobial activity. The acute oral toxicity study for the compound 3e and 3n have revealed good safety profile till the uppermost dose (2000 mg/kg).
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Keywords
2,4 disubstituted thiazole derivative, 3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone, 3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1, 3 thiazol 2 yl)hydrazone, 3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone, 3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone, 3 (phenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone, 3 (phenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3-thiazol 2 yl)hydrazone, 3 (phenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone, 3 aryl 1h pyrazole 4 carbaldehyde thiosemicarbazone derivative, bromine derivative, butylcresol, carbon, fluconazole, hydrogen, nitrogen, phenacyl bromide derivative, thiazole derivative, thiosemicarbazone derivative, unclassified drug, animal experiment, antimicrobial activity, antioxidant activity, article, controlled study, drug safety, drug screening, drug synthesis, female, infrared spectroscopy, male, mass spectrometry, mouse, nonhuman, nuclear magnetic resonance spectroscopy
Citation
International Journal of Pharmaceutical Research, 2012, 4, 3, pp. 81-88