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Author: search.filters.author.Das, U.K.Subject: search.filters.subject.ammonium acetate

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    An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
    (HeteroCorporation support@jhetchem.com, 2015) Bhat, S.I.; Das, U.K.; Trivedi, D.R.
    An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.