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A catalyst- and solvent-free three-component reaction for the regioselective one-pot access to polyfunctionalized pyrroles
(2013) Bhat, S.I.; Trivedi, D.R.
A facile method for the regioselective synthesis of tetrasubstituted pyrroles, from readily accessible 1,3-dicarbonyls, benzoin derivatives and ammonium acetate, has been developed. The one-pot three-component reactions were performed to afford tetrasubstituted pyrroles under solvent- and catalyst-free conditions. © 2013 Elsevier Ltd. All rights reserved.
An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
(HeteroCorporation support@jhetchem.com, 2015) Bhat, S.I.; Das, U.K.; Trivedi, D.R.
An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.