Faculty Publications

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Author: search.filters.author.Bhat, S.I.Subject: search.filters.subject.X ray diffraction

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    Condensation of malononitrile with salicylaldehydes and o-aminobenzaldehydes revisited: Solvent and catalyst free synthesis of 4H-chromenes and quinolines
    (Royal Society of Chemistry, 2012) Bhat, S.I.; Choudhury, A.R.; Trivedi, D.R.
    The reaction of malononitrile with salicylaldehyde under solvent and catalyst free conditions was re-investigated using mechanochemical mixing, thermal heating and a direct crystallization process. The resulting condensation product by all three types of molecular activation, was found to be (2-amino-3-cyano-4H-chromene-4-yl)malononitrile, which is not the previously reported benzofuran-2-carbonitrile. The structure of the resulting chromene derivative was confirmed by FT-IR, MS, 1H, 13C NMR and single crystal and powder X-ray diffraction. The reaction pathway under neat conditions (mechanochemical mixing) at ambient temperature was monitored by IR spectral measurements. The versatility of the current green protocol was examined through the reaction of eleven derivatives of o-hydroxybenzaldehyde with malononitrile to obtain 2-amino-3-cyano-4H-chromene derivatives. In addition, malononitrile was further reacted with o-aminobenzaldehydes under neat conditions to yield quinoline derivatives. © 2012 The Royal Society of Chemistry.
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    An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
    (HeteroCorporation support@jhetchem.com, 2015) Bhat, S.I.; Das, U.K.; Trivedi, D.R.
    An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.