Conference Papers

Permanent URI for this collectionhttps://idr.nitk.ac.in/handle/123456789/28506

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Author: search.filters.author.Kumar, B.Y.S.

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    Compressive and swelling behavior of cuttlebone derived hydroxyapatite loaded PVA hydrogel implants for articular cartilage
    (American Institute of Physics Inc. subs@aip.org, 2018) Kumar, B.Y.S.; Mohan Kumar, G.C.; Isloor, A.M.
    Developing a novel antibacterial, nontoxic and biocompatible hydrogel with superior physio mechanical properties is still becoming a challenge. Herein, we synthesize hydroxyapatite (HA) powder from cuttlefish bone and prepare a series of stiff, tough, high strength, biocompatible hydrogel reinforced with HA by integrating glutaraldehyde into PVA/HA. Powder was characterized by SEM and XRD. Compressive strength and swelling properties are studied and compare the results with the properties of healthy natural articular cartilage. © 2018 Author(s).
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    Viscoelastic behavior of HAp reinforced polyvinyl alcohol composite hydrogel for tissue engineered articular cartilages
    (American Institute of Physics Inc. subs@aip.org, 2019) Kumar, B.Y.S.; Isloor, A.M.; Mohan Kumar, G.C.
    Polyvinyl alcohol (PVA) hydrogels have desirable characteristics for use as a soft tissue substitute. However, their low mechanical strength and biocompatibility hinder the wide range of biomedical application. Herein, hydroxyapatite blended PVA/HAp composite hydrogel was developed by freeze-thawing and annealing method. The microstructure and rheological properties such as storage and loss modulus are investigated. Samples showed a porous structure with interconnected porosity and HAp distributed uniformly in a PVA matrix. Further, the composite hydrogel showed favorable viscoelastic properties and is suitable for artificial articular cartilage replacement. © 2018 Author(s).
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    Structure and rheology of chitosan-nanohydroxyapatite composite hydrogel for soft tissue regeneration
    (American Institute of Physics Inc. subs@aip.org, 2020) Kumar, B.Y.S.; Isloor, A.M.; Periasamy, K.; Kumar, G.C.M.
    Chitosan (CS) hydrogels show desirable characteristics to use a soft tissue implants due to its biocompatibility, biodegradability and antimicrobial characteristics. However, the structural stability hinders its application in vivo. In the present work nanohydroxyapatite (HAp) was reinforced with chitosan hydrogel and to develop chitosan-hydroxyapatite (CS-HAp) composite hydrogel. The nanohydroxyapatite modifies the hydrogel network by promoting the secondary hydrogen bonds thereby enhances the mechanical stiffness. The elastic modulus could reach 10 kPa which is necessary for the proposed application. Overall, chitosan-hydroxyapatite composite hydrogels are the promising implant materials for next-generation soft tissue regeneration. © 2020 Author(s).