Journal Articles

Permanent URI for this collectionhttps://idr.nitk.ac.in/handle/123456789/19884

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Subject: search.filters.subject.Platelet adhesion

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    Cytocompatibility by MTT assay and platelet adhesion of Ti and Ti-6Al-4V coated with hydroxyapatite in different plasma gas atmospheres
    (Jaypee Brothers Medical Publishers (P) Ltd 4838/24 Ansari Road, Daryaganj New Delhi 110 002, 2017) Kotian, R.; Rao, P.P.; Madhyastha, P.; Shobha, K.L.; Satish Rao, B.S.S.; Ginjupalli, K.
    Aim: This study was performed to evaluate the biocompatibility of pure titanium and Ti-6Al-4V metals coated with hydroxyapatite (HA) by plasma spray using different plasma gas atmospheres. Materials and methods: The cell viabilities for each HA-coated sample in an atmosphere of argon, argon–hydrogen, nitrogen, and nitrogen–hydrogen were studied using MTT assay and platelet adhesion test. Results: The mean cell viabilities by MTT [3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide] assay of samples coated with HA in argon–hydrogen plasma atmosphere showed maximum cell viability at different time intervals compared with other coating atmospheres of argon–hydrogen, nitrogen, and nitrogen–hydrogen. A statistically significant value of cell viability (p < 0.001) was observed between and within the groups of argon, argon–hydrogen, nitrogen, and nitrogen–hydrogen plasma gas atmosphere. The platelet adhesion study showed agglomerates of platelet cells in some isolated regions of HA for all atmospheres. Significance: The results obtained in this study can serve as a guide for the development of new Ti-based HA-coated implants in different plasma gas atmospheres. © 2017, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved.
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    Hemocompatibility of Sulfuric Acid-Treated Metallocene Polyethylene and its Application in Reducing the Quantity of Medical Plastic Waste
    (Taylor and Francis Inc. 325 Chestnut St, Suite 800 Philadelphia PA 19106, 2017) Jaganathan, S.K.; Balaji, A.; Mohanadas, H.; Sivakumar, G.; Kasi, P.; SelvaKumar, M.; Kadiman, S.B.; Anandhan, S.; Faudzi, A.A.B.; Supriyanto, E.; Mandal, M.
    The hazards of dumping medical plastics have created a huge demand to reduce the quantity of plastic usage without compromising its quality. The metallocene synthesized polyethylene is one such advent, however, its clinical usage is limited by the problem of hemocompatibility. This study investigates the effect of sulfuric acid-induced changes in metallocene polyethylene. Fourier transform infrared spectroscopy analysis illustrated the addition of OH and sulfonic acid group, which subsequently increased the wettability. An improvement in micro as well as nanosurface roughness was observed. Ultimately, the treated surfaces depicted delayed clotting time, adsorption of specific plasma proteins, reduced hemolysis, and resistance against platelet adhesion. © 2017 Taylor & Francis.