Journal Articles

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Author: search.filters.author.Nayak, K.H.Subject: search.filters.subject.Article

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    Metal-Free Bisamidation of N-Tosylhydrazones with Carboxylic Acids Promoted by Tetrabutylammonium Iodide and tert-Butyl Hydroperoxide
    (American Chemical Society, 2024) Shamnad, A.; Nayak, K.H.; Babu, B.P.
    A versatile reaction between N-tosylhydrazones and carboxylic acids to access bisamides is reported. This metal-free, room-temperature reaction was catalyzed by TBAI, while TBHP served as the oxidant. Broad substrate scope and good functional group tolerance are the key features of the strategy. Subsequent intramolecular N-arylation of suitably substituted bisamides readily afforded functionalized 3-indazolones. © 2024 American Chemical Society
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    Base-promoted multicomponent synthesis of 1,2,4-triazole-based hybrids from 1,3-diones, β-nitrostyrenes, and hydrazones
    (Royal Society of Chemistry, 2024) Sreelekha, M.K.; Jijin, R.K.; Nayak, K.H.; Babu, B.P.
    Herein, we report a metal-free, base-promoted route for the synthesis of hybrid molecular scaffolds in which various 1,3-diones and 1,2,4-triazoles are linked by a benzyl bridge. This three-component, one-pot reaction was accomplished by first treating 4-hydroxycoumarin, trans-β-nitrostyrene, and aldehyde hydrazone in the presence of sodium carbonate. Further, this protocol was successfully expanded to other 1,3-diones, such as dimedone and 4-hydroxy-2-quinolone. A broad substrate scope, mild reaction conditions, and the metal and ligand/additive-free approach are the prominent features of this strategy. © 2024 The Royal Society of Chemistry.