Base-promoted multicomponent synthesis of 1,2,4-triazole-based hybrids from 1,3-diones, β-nitrostyrenes, and hydrazones
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Herein, we report a metal-free, base-promoted route for the synthesis of hybrid molecular scaffolds in which various 1,3-diones and 1,2,4-triazoles are linked by a benzyl bridge. This three-component, one-pot reaction was accomplished by first treating 4-hydroxycoumarin, trans-β-nitrostyrene, and aldehyde hydrazone in the presence of sodium carbonate. Further, this protocol was successfully expanded to other 1,3-diones, such as dimedone and 4-hydroxy-2-quinolone. A broad substrate scope, mild reaction conditions, and the metal and ligand/additive-free approach are the prominent features of this strategy. © 2024 The Royal Society of Chemistry.
Description
Keywords
Scaffolds (biology), 4-Hydroxycoumarin, Free basis, Hydrazones, Metal free, Molecular scaffolds, Multicomponent synthesis, Nitrostyrene, One-pot reaction, Sodium carbonate, Three-component, Scaffolds, 1 2 4 triazole, 1 3 diones, 4 hydroxy 2 quinolone, 4 hydroxycoumarin, 5,5 dimethyl 1,3 cyclohexanedione, aldehyde hydrazone, chemical compound, dimethyl sulfoxide, quinolone, sodium carbonate, trans beta nitrostyrene, unclassified drug, aldehyde, hydrazone derivative, molecular scaffold, triazole derivative, Article, drug synthesis, X ray analysis, adult, article, controlled study, drug analysis, drug development, female, hybrid, male, synthesis
Citation
Chemical Communications, 2024, 60, 82, pp. 11718-11721