Browsing by Author "Isloor, N.A."

Now showing 1 - 6 of 6

2-Cyclopentylidenehydrazinecarboxamide
(2012) Fun, H.-K.; Loh, W.-S.; Padaki, M.; Isloor, A.M.; Isloor, N.A.
The asymmetric unit of the title compound, C6H 11N3O, consists of two independent molecules in which the cyclo-pentane rings adopt envelope conformations with CH2 grouping as the flap and the semicarbazone groups are essentially planar, with maximums deviation of 0.0311 (12) and 0.0285 (12) . In the crystal, N - H?O, N - H?N and C - H?O hydrogen bonds link the molecules to form sheets lying parallel to the ab plane.
Hantzsch reaction: Synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents
(2011) Vijesh, A.M.; Isloor, A.M.; Peethambar, S.K.; Shivananda, K.N.; Arulmoli, T.; Isloor, N.A.
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized by IR, NMR, mass spectral study and also by C, H, N analyses. New compounds were screened for their antimicrobial activity by well plate method (zone of inhibition). Antioxidant studies of the synthesized compounds were also performed by measuring the DPPH radical scavenging assay. Compounds 4c, 4e and 4f were found to be potent antibacterial and antioxidant agents. The acute oral toxicity study for the compounds 4c, 4e and 4f were carried out and the experimental studies revealed that compounds 4c and 4e is safe up to 3000 mg/kg and no death of animals were recorded. However in compound 4f, we found mortality above 2000 mg and also significant behavioral changes in experimental animals. 2011 Elsevier Masson SAS. All rights reserved.
Syntheses, crystal structures and antimicrobial studies of two new semicarbazone derivatives
(2014) Chia, T.S.; Quah, C.K.; Ooi, C.W.; Garudachari, B.; Isloor, N.A.; Isloor, A.M.; Fun, H.-K.
Two new derivatives of semicarbazone, (E)-2-(hexan-2-ylidene) hydrazinecarboxamide and (E)-2-(heptan-2-ylidene)hydrazinecarboxamide were synthesized and characterized by IR and 1H NMR. Their crystal structures were characterized by X-ray diffraction method. Compound (I) crystallizes in triclinic P 1 ?, a = 6.7679(7) , b = 7.1912(8) , c = 9.9969(11) , ? = 108.824(2), ? = 99.398(3), ? = 92.680(2), V = 451.75(8) 3, Z = 2, R 1 = 0.043 and wR 2 = 0.140. Compound (II) crystallizes in triclinic P 1 ?, a = 6.7192(6) , b = 7.2094(6) , c = 11.2842(11) , ? = 103.303(2), ? = 106.198(2), ? = 91.219(1), V = 508.70(8) 3, Z = 2, R 1 = 0.044 and wR 2 = 0.133. Their molecules adopt a L-shape conformation with C atom in C=N double bond acting as the junction point. The C=O double bond indicate the existence of semicarbazone group in keto-like form for both compounds in their solid state. In the crystal, the carbonyl O atom for both derivatives acts as a common acceptor in the intermolecular bifurcated N-H O hydrogen bonding which linked the molecules into one-dimensional supramolecular ribbons. Antimicrobial studies by serial dilution method showed both compounds exhibit antibacterial property. Graphical Abstract: Two new semicarbazone derivatives are characterized by IR, 1H NMR and single crystal X-ray diffraction methods and their antibacterial activity was further investigated by screening against four different bacterial strains.[Figure not available: see fulltext.] 2013 Springer Science+Business Media New York.
Syntheses, crystal structures and antimicrobial studies of two new semicarbazone derivatives
(2014) Chia, T.S.; Ching Kheng, C.K.; Ooi, C.W.; Garudachari, B.; Isloor, N.A.; Isloor, A.M.; Fun, H.-K.
Two new derivatives of semicarbazone, (E)-2-(hexan-2-ylidene) hydrazinecarboxamide and (E)-2-(heptan-2-ylidene)hydrazinecarboxamide were synthesized and characterized by IR and 1H NMR. Their crystal structures were characterized by X-ray diffraction method. Compound (I) crystallizes in triclinic P 1 ?, a = 6.7679(7) Å, b = 7.1912(8) Å, c = 9.9969(11) Å, ? = 108.824(2), ? = 99.398(3), ? = 92.680(2), V = 451.75(8) Å3, Z = 2, R 1 = 0.043 and wR 2 = 0.140. Compound (II) crystallizes in triclinic P 1 ?, a = 6.7192(6) Å, b = 7.2094(6) Å, c = 11.2842(11) Å, ? = 103.303(2), ? = 106.198(2), ? = 91.219(1), V = 508.70(8) Å3, Z = 2, R 1 = 0.044 and wR 2 = 0.133. Their molecules adopt a L-shape conformation with C atom in C=N double bond acting as the junction point. The C=O double bond indicate the existence of semicarbazone group in keto-like form for both compounds in their solid state. In the crystal, the carbonyl O atom for both derivatives acts as a common acceptor in the intermolecular bifurcated N-H·O hydrogen bonding which linked the molecules into one-dimensional supramolecular ribbons. Antimicrobial studies by serial dilution method showed both compounds exhibit antibacterial property. Graphical Abstract: Two new semicarbazone derivatives are characterized by IR, 1H NMR and single crystal X-ray diffraction methods and their antibacterial activity was further investigated by screening against four different bacterial strains.[Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York.
Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
(2013) Ubaradka, S.R.; Isloor, A.M.; Shetty, P.; Shetty, P.; Isloor, N.A.
In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. 2012 Springer Science+Business Media, LLC.
Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
(2013) Ubaradka, S.R.; Isloor, A.M.; Shetty, P.; Shetty, P.; Isloor, N.A.
In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. © 2012 Springer Science+Business Media, LLC.