Browsing by Author "Fun, H.-K."

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1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies
(2015) Harikrishna, N.; Isloor, A.M.; Ananda, K.; Obaid, A.; Fun, H.-K.
A new series 3-{2-[N?-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 ?g ml-1 for a few of the synthesized compounds. The Royal Society of Chemistry 2015.
1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies
(Royal Society of Chemistry, 2015) Harikrishna, N.; Isloor, A.M.; Kulal, K.; AlObaid, A.; Fun, H.-K.
A new series 3-{2-[N?-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 ?g ml-1 for a few of the synthesized compounds. © The Royal Society of Chemistry 2015.
1-[(3-Benz-yloxy-2-nitro-phen-oxy)meth-yl]benzene
(2012) Fun, H.-K.; Arshad, S.; Ubaradka, S.R.; Shetty, P.; Isloor, A.M.
The asymmetric unit of the title compound, C20H17NO4, consists of two crystallographically independent mol-ecules. In one of the mol-ecules, the central benzene ring forms dihedral angles of 2.26 (6) and 58.68 (6) with the terminal benzene rings and the dihedral angle between the terminal benzene rings is 56.45 (6) . The corresponding values for the other mol-ecule are 35.17 (6), 70.97 (6) and 69.62 (6) , respectively. In the crystal, an inversion dimer linked by a pair of C-H?O hydrogen bonds occurs for one of the unique mol-ecules. C-H?? and ?-? [centroid-centroid distances = 3.7113 (8) and 3.7216 (7) ] inter-actions link the components into a three-dimensional network.
1-[(3-Benz-yloxy-2-nitro-phen-oxy)meth-yl]benzene
(2012) Fun, H.-K.; Arshad, S.; Ubaradka, S.R.; Shetty, P.; Isloor, A.M.
The asymmetric unit of the title compound, C20H17NO4, consists of two crystallographically independent mol-ecules. In one of the mol-ecules, the central benzene ring forms dihedral angles of 2.26 (6) and 58.68 (6)°with the terminal benzene rings and the dihedral angle between the terminal benzene rings is 56.45 (6)°. The corresponding values for the other mol-ecule are 35.17 (6), 70.97 (6) and 69.62 (6)°, respectively. In the crystal, an inversion dimer linked by a pair of C-H?O hydrogen bonds occurs for one of the unique mol-ecules. C-H?? and ?-? [centroid-centroid distances = 3.7113 (8) and 3.7216 (7) Å] inter-actions link the components into a three-dimensional network.
1-Cyclohexyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxy-lic acid
(2011) Fun, H.-K.; Quah, C.K.; Chandrakantha, B.; Isloor, A.M.; Shetty, P.
In the title compound, C17H20N2O 3, the meth-oxy-phenyl unit is disordered over two sets of sites in a 0.715 (4):0.285 (4) ratio. The pyrazole ring forms dihedral angles of 55.88 (16) and 72.6 (4) with the benzene rings of its major and minor components, respectively. The cyclohexane ring adopts a chair conformation and its C-N bond is in an equatorial orientation. In the crystal, molecules are linked into inversion dimers by pairs of O-H?O hydrogen bonds, generating R 2 2(8) loops..
1-Cyclohexyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxy-lic acid
(2011) Fun, H.-K.; Ching Kheng, C.K.; Chandrakantha, B.; Isloor, A.M.; Shetty, P.
In the title compound, C17H20N2O 3, the meth-oxy-phenyl unit is disordered over two sets of sites in a 0.715 (4):0.285 (4) ratio. The pyrazole ring forms dihedral angles of 55.88 (16) and 72.6 (4)°with the benzene rings of its major and minor components, respectively. The cyclohexane ring adopts a chair conformation and its C-N bond is in an equatorial orientation. In the crystal, molecules are linked into inversion dimers by pairs of O-H?O hydrogen bonds, generating R 2 2(8) loops..
1-Dibromomethyl-4-methoxy-2-nitrobenzene
(2009) Fun, H.-K.; Goh, J.H.; Chandrakantha, B.; Isloor, A.M.
The asymmetric unit of the title compound, C8H 7Br2NO3, comprises two crystallographically independent molecules (A and B). The nitro groups are twisted from the attached benzene rings, making dihedral angles of 39.26 (9) and 35.90 (9) in molecules A and B, respectively. In each mol-ecule, the dibromo-methyl group is orientated in such a way that the two Br atoms are tilted away from the benzene ring. An inter-esting features of the crystal structure is the two short Br?Br inter-actions which, together with inter-molecular C - H?O hydrogen bonds, link the molecules into an extended three-dimensional network. The crystal structure is further stabilized by weak C - H?? inter-actions. Fun et al. 2009.
1-Dibromomethyl-4-methoxy-2-nitrobenzene
(2009) Fun, H.-K.; Goh, J.H.; Chandrakantha, B.; Isloor, A.M.
The asymmetric unit of the title compound, C8H 7Br2NO3, comprises two crystallographically independent molecules (A and B). The nitro groups are twisted from the attached benzene rings, making dihedral angles of 39.26 (9) and 35.90 (9)° in molecules A and B, respectively. In each mol-ecule, the dibromo-methyl group is orientated in such a way that the two Br atoms are tilted away from the benzene ring. An inter-esting features of the crystal structure is the two short Br?Br inter-actions which, together with inter-molecular C - H?O hydrogen bonds, link the molecules into an extended three-dimensional network. The crystal structure is further stabilized by weak C - H?? inter-actions. © Fun et al. 2009.
(1Z)-1-(2,4-Dichloro-phen-yl)ethan-1-one semicarbazone
(2009) Fun, H.-K.; Balasubramani, K.; Vijesh, A.M.; Malladii, S.; Isloor, A.M.
In the title compound, C9H9Cl2N 3O, the semicarbazone group is approximately planar, with an r.m.s deviation from the mean plane of 0.011 (2) . The dihedral angle between the least-squares planes through the semicarbazone group and the benzene ring is 38.76 (9) . The crystal structure is further stabilized by N - H?O and C - H?O hydrogen bonding. Fun et al. 2009.
(1Z)-1-(2,4-Dichloro-phen-yl)ethan-1-one semicarbazone
(2009) Fun, H.-K.; Balasubramani, K.; Vijesh, A.M.; Malladii, S.; Isloor, A.M.
In the title compound, C9H9Cl2N 3O, the semicarbazone group is approximately planar, with an r.m.s deviation from the mean plane of 0.011 (2) Å. The dihedral angle between the least-squares planes through the semicarbazone group and the benzene ring is 38.76 (9)°. The crystal structure is further stabilized by N - H?O and C - H?O hydrogen bonding. © Fun et al. 2009.
2,6-Dichloro-3-nitro-pyridine
(2011) Fun, H.-K.; Arshad, S.; Chandrakantha, B.; Isloor, A.M.; Shetty, P.
The asymmetric unit of the title compound, C 5H 2C l2N 2O 2, consists of two crystallographically independent mol-ecules. The pyridine ring in each mol-ecule is essentially planar, with maximum deviations of 0.004 (4) and 0.007 (4) . Short Cl?O [3.09 (3) and 3.13 (4) ] and Cl?Cl [3.38 (12) ] contacts were observed. No significant inter-molecular inter-actions were observed in the crystal packing. Fun et al. 2011.
2,6-Dichloro-3-nitro-pyridine
(2011) Fun, H.-K.; Arshad, S.; Chandrakantha, B.; Isloor, A.M.; Shetty, P.
The asymmetric unit of the title compound, C 5H 2C l2N 2O 2, consists of two crystallographically independent mol-ecules. The pyridine ring in each mol-ecule is essentially planar, with maximum deviations of 0.004 (4) and 0.007 (4) Å. Short Cl?O [3.09 (3) and 3.13 (4) Å] and Cl?Cl [3.38 (12) Å] contacts were observed. No significant inter-molecular inter-actions were observed in the crystal packing. © Fun et al. 2011.
2-(2,4-Dichlorophenyl)-2-oxoethyl 4-methoxybenzoate
(2011) Fun, H.-K.; Chia, T.S.; Shenvi, S.; Isloor, A.M.; Garudachari, B.
In the title compound, C16H12Cl2O 4, the dihedral angle between the benzene rings is 70.11 (6) . In the crystal, molecules are linked by C-H?O hydrogen bonds into a three-dimensional network. A C-H?? inter-action is also observed.
2-(2,4-Dichlorophenyl)-2-oxoethyl 4-methoxybenzoate
(2011) Fun, H.-K.; Chia, T.S.; Shenvi, S.S.; Isloor, A.M.; Garudachari, B.
In the title compound, C16H12Cl2O 4, the dihedral angle between the benzene rings is 70.11 (6)°. In the crystal, molecules are linked by C-H?O hydrogen bonds into a three-dimensional network. A C-H?? inter-action is also observed.
2-(2-Chloro-phenoxy)acetohydrazide
(2010) Fun, H.-K.; Quah, C.K.; Isloor, A.M.; Sunil, D.; Shetty, P.
In the title compound, C8H9ClN2O 2, the acetohydrazide group is approximately planar, with the maximum deviation of 0.031 (2) . In the crystal, the mol-ecules are linked by N-H?N, N-H?O and C-H?O hydrogen bonds, with the acetohydrazide O atom accepting two C-H?O links and one N-H?O link. This results in infinite sheets lying parallel to (100).
2-(2-Chloro-phenoxy)acetohydrazide
(2010) Fun, H.-K.; Ching Kheng, C.K.; Isloor, A.M.; Dhanya, D.; Shetty, P.
In the title compound, C8H9ClN2O 2, the acetohydrazide group is approximately planar, with the maximum deviation of 0.031 (2) Å. In the crystal, the mol-ecules are linked by N-H?N, N-H?O and C-H?O hydrogen bonds, with the acetohydrazide O atom accepting two C-H?O links and one N-H?O link. This results in infinite sheets lying parallel to (100).
2-(4-Bromo-phen-yl)-2-oxoethyl 2-meth-oxy-benzoate
(2011) Fun, H.-K.; Quah, C.K.; Garudachari, B.; Isloor, A.M.; Satyanarayan, M.N.
In the title mol-ecule, C 16H 13BrO 4, the dihedral angle between the benzene rings is 85.92 (10) . In the crystal, mol-ecules are linked into chains along [100] via weak inter-molecular C - H?O hydrogen bonds. Fun et al. 2011.
2-(4-Bromo-phen-yl)-2-oxoethyl 2-meth-oxy-benzoate
(2011) Fun, H.-K.; Ching Kheng, C.K.; Garudachari, B.; Isloor, A.M.; Satyanarayan, M.N.
In the title mol-ecule, C 16H 13BrO 4, the dihedral angle between the benzene rings is 85.92 (10)°. In the crystal, mol-ecules are linked into chains along [100] via weak inter-molecular C - H?O hydrogen bonds. © Fun et al. 2011.
2-(4-Bromo-phen-yl)-2-oxoethyl 4-bromo-benzoate
(2011) Fun, H.-K.; Arshad, S.; Garudachari, B.; Isloor, A.M.; Satyanarayan, M.N.
The asymmetric unit of the title compound, C 15H 10Br 2O 3, consists of three crystallographically independent mol-ecules (A, B and C). The phenyl rings in mol-ecules A, B and C make dihedral angles of 6.1 (3), 3.2 (2) and 54.6 (2) to each other, respectively. In the crystal, mol-ecules are linked into two-dimensional layers parallel to the ab plane by inter-molecular C - H?O hydrogen bonds. The crystal structure is further stabilized by C - H?? inter-actions. The studied crystal is an inversion twin, the refined ratio of the twin components being 0.128 (8):0.872 (8). Fun et al. 2011.
2-(4-Bromo-phen-yl)-2-oxoethyl 4-bromo-benzoate
(2011) Fun, H.-K.; Arshad, S.; Garudachari, B.; Isloor, A.M.; Satyanarayan, M.N.
The asymmetric unit of the title compound, C 15H 10Br 2O 3, consists of three crystallographically independent mol-ecules (A, B and C). The phenyl rings in mol-ecules A, B and C make dihedral angles of 6.1 (3), 3.2 (2) and 54.6 (2)° to each other, respectively. In the crystal, mol-ecules are linked into two-dimensional layers parallel to the ab plane by inter-molecular C - H?O hydrogen bonds. The crystal structure is further stabilized by C - H?? inter-actions. The studied crystal is an inversion twin, the refined ratio of the twin components being 0.128 (8):0.872 (8). © Fun et al. 2011.