Malladi, S.Isloor, A.M.Peethambar, S.K.Fun, H.-K.2026-02-052013Medicinal Chemistry Research, 2013, 22, 6, pp. 2654-266410542523https://doi.org/10.1007/s00044-012-0267-8https://idr.nitk.ac.in/handle/123456789/26780New (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 6 (pyrazolic chalcones) were synthesized from Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 5. Subsequently, the cyclocondensation reaction of chalcones 6 with phenylhydrazine in acetic acid medium afforded the new 3-aryl-4-(3-aryl-4,5- dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7. The synthesized compounds were characterized by spectral studies and evaluated for their in vitro antibacterial activity against three pathogenic bacterial strains, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and in vitro antifungal activity against three pathogenic fungal strains Aspergillus flavus, Chrysosporium keratinophilum, and Candida albicans. © 2012 Springer Science+Business Media New York.3 (4 bromophenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole3 (4 bromophenyl) 4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 pheny 1h pyrazole3 (4 bromophenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole3 (4 chlorophenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole3 (4 chlorophenyl) 4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 pheny 1h pyrazole3 (4 chlorophenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole3 (4 methoxyphenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole3 (4 methoxyphenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole3 aryl 4 (3 aryl 4,5 dihydro 1h pyrazol 5 yl) 1 phenyl 1h pyrazole derivative4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1,3 diphenyl 1h pyrazole4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1,3 dipheyl 1h pyrazoleantibiotic agentantifungal agentfluconazolepyrazole derivativestreptomycinunclassified drugantibacterial activityantifungal activityarticleAspergillus flavusCandida albicanschrysosporium keratinophilumcontrolled studydrug synthesisEscherichia colifungusin vitro studyinfrared spectroscopynonhumanproton nuclear magnetic resonancePseudomonas aeruginosaStaphylococcus aureus