Gopkumar, P.Mugeraya, G.2026-02-052010Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2010, 1, 3, pp. 826-831https://idr.nitk.ac.in/handle/123456789/27444In the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity.Adhathoda vasica extractalkaloidchloramphenicolketoconazoleplant extractunclassified drugvasicinevasicinoneAdhathoda vasicaantimicrobial activityarticleAspergillus nigerbiocatalysisbiotransformationCandida albicanscontrolled studydrug isolationdrug screeningEscherichia colifungal biotransformationfungushumanmass fragmentographymedicinal plantoutcome assessmentPencillium notatumproton nuclear magnetic resonancePseudomonas aeruginosaRhizopusStaphylococcus aureusthin layer chromatographyTrematus versicolorRhizopus oryzaeTetra