Isloor, A.M.Kalluraya, B.Shetty, P.2026-02-052009European Journal of Medicinal Chemistry, 2009, 44, 9, pp. 3784-37872235234https://doi.org/10.1016/j.ejmech.2009.04.038https://idr.nitk.ac.in/handle/123456789/27598In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, 1H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity. © 2009 Elsevier Masson SAS. All rights reserved.1 methylpiperazine1,2,4 triazole derivative2 [(4 methylpiperazin 1 yl)methyl] 2h 1,2,4 triazole 3(4h) thione derivativeformaldehydeMannich basenitrofuralpiperazine derivativeunclassified drugantifungal activityantimicrobial activityarticledrug synthesismass spectrometryminimum inhibitory concentrationnonhumanproton nuclear magnetic resonancereaction analysisstereochemistrystructure activity relationAnti-Bacterial AgentsAnti-Infective AgentsAntifungal AgentsBacteriaCandida albicansMannich BasesMicrobial Sensitivity TestsStructure-Activity RelationshipTriazoles