Chanchal, A.K.Kumar, A.Lal, S.Kini, J.2026-02-052021Computers and Electrical Engineering, 2021, 92, , pp. -457906https://doi.org/10.1016/j.compeleceng.2021.107177https://idr.nitk.ac.in/handle/123456789/23204Image segmentation is consistently an important task for computer vision and the analysis of medical images. The analysis and diagnosis of histopathology images by using efficient algorithms that separate hematoxylin and eosin-stained nuclei was the purpose of our proposed method. In this paper, we propose a deep learning model that automatically segments the complex nuclei present in histology images by implementing an effective encoder–decoder architecture with a separable convolution pyramid pooling network (SCPP-Net). The SCPP unit focuses on two aspects: first, it increases the receptive field by varying four different dilation rates, keeping the kernel size fixed, and second, it reduces the trainable parameter by using depth-wise separable convolution. Our deep learning model experimented with three publicly available histopathology image datasets. The proposed SCPP-Net provides better experimental segmentation results compared to other existing deep learning models and is evaluated in terms of F1-score and aggregated Jaccard index. © 2021 Elsevier LtdDeep learningDiagnosisDiseasesImage analysisImage segmentationMedical imagingNetwork architectureBreast CancerHaematoxylinImages segmentationsKidney cancerLearning architecturesLearning modelsNucleus segmentationPyramid poolingSeparable convolutionConvolution