Chandrakantha, B.Isloor, A.M.Shetty, P.Fun, H.-K.Hegde, G.2026-02-052014European Journal of Medicinal Chemistry, 2014, 71, , pp. 316-3232235234https://doi.org/10.1016/j.ejmech.2013.10.056https://idr.nitk.ac.in/handle/123456789/26539A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2- yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)- 3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.© 2013 Elsevier Masson SAS. All rights reserved.(2,4 difluoro benzyl) [4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl) 2 nitro phenyl) aminei(4 fluoro phenyl) [4 [6(4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl] amine2,2 dimethyl n (5 [3 nitro 4 [4 (4 trifluoromethyl phenyl) piperdin 1 yl] phenyl) [1,3,4] thiadiazol 2 yl) propionamide2,2 dimethyl n (5 [3 nitro 4 [tetrahydro furan 2 ylmethyl) amino] phenyl] [1,3,4] thiadiazol 2 yl) propionamide2,2 dimethyl n [5 (4 morpholin 4 yl 3 nitro phenyl) [1,3,4] thiadiazo 2 yl] propionamide2,2 dimethyl n [5 [4 (4 methyl piperazin 1 yl) 3 nitro phenyl] [1,3,4]thiadiazol 2 yl) propionamide6 (4 methoxy phenyl) 2 (3 nitro 4 pyrrolidin 1 yl phenyl) imidazo [2,1 b] [1,3,4] thiadiazol6 (4 methoxy phenyl) 2 [3 nitro 4 [4 (4 trifluoromethyl phenyl) piperidine 1 yl] phenyl imidazo6 (4 methoxy phenyl) 2 [4 (4 methyl piperazin 1 yl) 3 nitro phenyl] imidazo [2,1 b] [1,3,4] thiadiazole6 (4 methoxy phenyl) 2 [4 morpholin 4 1 yl) 3 nitro phenyl] imidazo [2,1 b] [1,3,4 thiadiazoleantifungal agentantiinfective agentbutyl [4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) aminecyclohexyl [4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) aminecyclopentyl [4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) aminediethyl [4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) aminen [5 (3 nitro 4 pyrrolidin 1 yl phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 (4 butylamino 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 (4 cyclohexylamino 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 (4 cyclopentylamino 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 (4 diethylamino 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 (4 dimethylamino 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamiden [5 [4 (2,4 di fluoro benzylamino) 3 nitro phenyl) [1,3,4] thiadiazol 2 yl] 2,2 dimethyl propionamidethiadiazole derivativeunclassified drug[4 [6 (4 methoxy phenyl) imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) dimethyl amine[4 [6 (4 methoxy phenyl)imidazo [2,1 b] [1,3,4] thiadiazol 2 yl] 2 nitro phenyl) (tetrahydro furan 2 ylmethyl) amineantibacterial activityantifungal activityantimicrobial activityarticleAspergillus flavusBacillus subtilisCandida albicanscarbon nuclear magnetic resonanceChrysosporiumdrug synthesisEscherichia colifungal strainproton nuclear magnetic resonancePseudomonas aeruginosa1,3,4-Thiadiazole2,6-Diaryl imidazo [2,1-b] [1,3,4] thiadiazoleAntibacterialAntifungal activityAnti-Bacterial AgentsAntifungal AgentsBacteriaBacterial InfectionsFungiHumansMicrobial Sensitivity TestsMycosesThiadiazoles