Shamnad, A.Nayak, K.H.Babu, B.P.2026-02-042024Journal of Organic Chemistry, 2024, 89, 9, pp. 6545-6554223263https://doi.org/10.1021/acs.joc.4c00156https://idr.nitk.ac.in/handle/123456789/21137A versatile reaction between N-tosylhydrazones and carboxylic acids to access bisamides is reported. This metal-free, room-temperature reaction was catalyzed by TBAI, while TBHP served as the oxidant. Broad substrate scope and good functional group tolerance are the key features of the strategy. Subsequent intramolecular N-arylation of suitably substituted bisamides readily afforded functionalized 3-indazolones. © 2024 American Chemical SocietyFunctionalizedKey featureMetal freeN-arylationsN-tosylhydrazonesTert-butylhydroperoxideCarboxylic acidscarboxylic acidfunctional grouphydrazone derivativeindazole derivativetert butyl hydroperoxidetetrabutylammoniumtoluenesulfonic acid derivativeamidationArticlearylationcatalysiscontrolled studyquantum yieldreaction analysisreaction optimization