Vijesh, A.M.Isloor, A.M.Shetty, P.Sundershan, S.Fun, H.-K.2026-02-052013European Journal of Medicinal Chemistry, 2013, 62, , pp. 410-4152235234https://doi.org/10.1016/j.ejmech.2012.12.057https://idr.nitk.ac.in/handle/123456789/26808Azole class of compounds are well known for their excellent therapeutic properties. Present paper describes about the synthesis of three series of new 1,2,4-triazole and benzoxazole derivatives containing substituted pyrazole moiety (11a-d, 12a-d and 13a-d). The newly synthesized compounds were characterized by spectral studies and also by C, H, N analyses. All the synthesized compounds were screened for their analgesic activity by the tail flick method. The antimicrobial activity of the new derivatives was also performed by Minimum Inhibitory Concentration (MIC) by the serial dilution method. The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity. © 2012 Elsevier Masson SAS. All rights reserved.analgesic agentantibiotic agentantifungal agentbenzoxazole derivativeceftriaxonefluconazolepentazocinepyrazole derivativeanalgesic activityanimal experimentanimal modelantibacterial activityantifungal activityarticleBacillus subtilisCandida albicanscarbon nuclear magnetic resonancecontrolled studydilutiondrug screeningdrug synthesisEscherichia colimaleminimum inhibitory concentrationnitrogen nuclear magnetic resonancenonhumanproton nuclear magnetic resonancePseudomonas aeruginosaratStaphylococcus aureustail flick testAnalgesicsAnimalsAnti-Bacterial AgentsAntifungal AgentsBacteriaBenzoxazolesDose-Response Relationship, DrugFungiMicrobial Sensitivity TestsMolecular StructurePainPain MeasurementPyrazolesRatsRats, WistarStructure-Activity RelationshipTriazoles