Marques-Da-Silva, D.Fraqueza, G.Lagoa, R.Anandan Vannathan, A.A.Mal, S.S.Aureliano, M.2026-02-052019New Journal of Chemistry, 2019, 43, 45, pp. 17577-1758711440546https://doi.org/10.1039/c9nj01208ghttps://idr.nitk.ac.in/handle/123456789/24803Recently, a global analysis of the structure-activity-relationship of a series of polyoxometalates (POMs) revealed that the most active POMs were ascribed to be polyoxovanadates (POVs), especially decavanadate (V<inf>10</inf>), which was very active against certain bacteria (Bijelic et al., Chem. Commun., 2018). The present study explores this observation and compares the effects of three POVs namely MnV<inf>11</inf>, MnV<inf>13</inf> and V<inf>10</inf> against Escherichia coli growth. It was observed that MnV<inf>11</inf> presents the lowest growth inhibition (GI<inf>50</inf>) value for Escherichia coli followed by the MnV<inf>13</inf> compound, being about 2 times lower than that of V<inf>10</inf>; respectively, the values obtained were 0.21, 0.27 and 0.58 mM. All three compounds were more effective than vanadate alone (GI<inf>50</inf> = 1.1 mM) and also than decaniobate, Nb<inf>10</inf> (GI<inf>50</inf> > 10 mM), an isostructural POM of V<inf>10</inf>. However, the POVs exhibiting the highest antibacterial activity (MnV<inf>11</inf>) were shown to have the lowest Ca2+-ATPase inhibitor capacity (IC<inf>50</inf> = 58 ?M) whereas decavanadate, which was also very active against this membranar ATPase (IC<inf>50</inf> = 15 ?M), was less active against bacterial growth, suggesting that POV inhibition of ion pumps might not be associated with the inhibition of Escherichia coli growth. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.adenosine triphosphatase (calcium)ammonium vanadatecalcium ionophoredecavanadatepolyoxovanadatesarcoplasmic reticulum calcium transporting adenosine triphosphataseunclassified drugvanadic acidantibacterial activityArticlecalcium homeostasiscell culturecontrolled studydensitometrydepolymerizationdrug decompositiondrug potencydrug solubilityenzyme activityenzyme inhibitionEscherichia coliGI50Helicobacter pyloriIC50nonhumanoptical densitypolyacrylamide gel electrophoresisprotein synthesis inhibitionsarcoplasmic reticulumsolubilizationStreptococcus pneumoniaestructure activity relationturbidityultraviolet visible spectroscopy