Sathish, N.K.Bhagavanraju, M.Hemamalini, K.Gopkumar, P.Narendra, V.Rajendra, Prasad, V.V.S.2020-03-312020-03-312007Asian Journal of Chemistry, 2007, Vol.19, 6, pp.4809-4816https://idr.nitk.ac.in/handle/123456789/13239A novel ?-[4-isopropyl phenyl]-4-(hydroxy diphenyl methyl)-1-piperidinyl)butan-1-one (II) has been synthesized by Friedel Craft's acylation and condensation reaction. The structures of the synthesized compounds were elucidated by (IR, PMR and Mass) spectral analysis. The compound synthesized was screened for anti-histaminic activity by histamine induced contractions using guinea pig ileum, anticholinergic by guinea pig tracheal chain and sedative activity. The compound exhibited significant anti-histaminic activity.Article