Dutta, S.2026-02-052020Carbohydrate Research, 2020, 497, , pp. -86215https://doi.org/10.1016/j.carres.2020.108140https://idr.nitk.ac.in/handle/123456789/23639In this work, 5-(formyloxymethyl)furfural (FMF) has been produced from biomass-derived hexose sugars within a biphasic reaction mixture consisting of aqueous formic acid (85%), a strong Brønsted acid catalyst, and 1,2-dichloroethane as an organic extractant. Using a combination of aqueous hydrobromic acid and formic acid, under optimized condition (80 °C, 8 h, 10 wt% substrate loading), 68% isolated yield of FMF was obtained from fructose. FMF has been demonstrated as a renewable chemical building block for the synthesis of renewable chemicals of commercial significance such as 5-methylfurfural, 2,5-diformylfuran, and 2,5-furandicarboxylic acid in good to excellent isolated yields. © 2020 Elsevier LtdAldehydesCatalystsFormic acidFurfuralSugars1 ,2-dichloroethanes2 ,5-furandicarboxylic acidsBiphasic reactionOptimized conditionsOrganic extractantRenewable chemicalsSubstrate loadingValue-added chemicalsIndicators (chemical)1,2 dichloroethane5 (formyloxymethyl)furfuralaldehyde derivativeBronsted acidformic acidfructosefuran derivativehexosehydrobromic acidhydroxyaldehydeunclassified drug5-methyl-2-furfuralcarbohydratefurfuralwateraqueous solutionArticlebiomasscatalysthydrolysispriority journalreaction analysisreaction optimizationrenewable resourcesolvent extractionsynthesiscatalysischemistryconformationmolecular modeltemperatureBiomassCarbohydrate ConformationCatalysisFormatesFuraldehydeModels, MolecularTemperatureWater