Bhat, S.I.Das, U.K.Trivedi, D.R.2026-02-052015Journal of Heterocyclic Chemistry, 2015, 52, 4, pp. 1253-12590022152Xhttps://doi.org/10.1002/jhet.2220https://idr.nitk.ac.in/handle/123456789/26261An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. © 2014 HeteroCorporation.2 aminoaryl ketone2 butyl 6 nitro 4 phenylquinazoline2 ethyl 6 nitro 4 phenylquinazoline2,4 diphenylquinazoline4 methyl 2 phenylquinazoline6 chloro 2,4 diphenylquinazoline6 chloro 4 (2 fluorophenyl) 2 methylquinazoline6,7 dimethoxy 2,4 dimethylquinazolineammonium acetateketone derivativequinazoline derivativesolventunclassified drugaromatizationArticlecatalystcyclizationdrug synthesiselectrongreen chemistryone pot synthesisreaction analysisreaction timespectroscopythin layer chromatographyX ray analysisX ray diffraction