Sreelekha, M.K.Jijin, R.K.Nayak, K.H.Babu, B.P.2026-02-042024Chemical Communications, 2024, 60, 82, pp. 11718-1172113597345https://doi.org/10.1039/d4cc03709jhttps://idr.nitk.ac.in/handle/123456789/20918Herein, we report a metal-free, base-promoted route for the synthesis of hybrid molecular scaffolds in which various 1,3-diones and 1,2,4-triazoles are linked by a benzyl bridge. This three-component, one-pot reaction was accomplished by first treating 4-hydroxycoumarin, trans-β-nitrostyrene, and aldehyde hydrazone in the presence of sodium carbonate. Further, this protocol was successfully expanded to other 1,3-diones, such as dimedone and 4-hydroxy-2-quinolone. A broad substrate scope, mild reaction conditions, and the metal and ligand/additive-free approach are the prominent features of this strategy. © 2024 The Royal Society of Chemistry.Scaffolds (biology)4-HydroxycoumarinFree basisHydrazonesMetal freeMolecular scaffoldsMulticomponent synthesisNitrostyreneOne-pot reactionSodium carbonateThree-componentScaffolds1 2 4 triazole1 3 diones4 hydroxy 2 quinolone4 hydroxycoumarin5,5 dimethyl 1,3 cyclohexanedionealdehyde hydrazonechemical compounddimethyl sulfoxidequinolonesodium carbonatetrans beta nitrostyreneunclassified drugaldehydehydrazone derivativemolecular scaffoldtriazole derivativeArticledrug synthesisX ray analysisadultarticlecontrolled studydrug analysisdrug developmentfemalehybridmalesynthesis