Rai, U.S.Isloor, A.M.Shetty, P.Isloor, N.Padaki, M.Fun, H.-K.2026-02-052012Medicinal Chemistry Research, 2012, 21, 7, pp. 1090-109710542523https://doi.org/10.1007/s00044-011-9607-3https://idr.nitk.ac.in/handle/123456789/26994An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity. © Springer Science+Business Media, LLC 2011.(1 benzofuran 2 yl but 3 eny) napthalen 1 yl amine(1 benzofuran 2 yl but enyl) (3,5 difluoro benzyl) amine(1 cyclohexyl but 3 enyl) (2,5 dimethyl phenyl) amine(1 cyclohexyl but 3 enyl) (4 morpholin 4 yl phenyl) amine(1 cyclopropyl but 3 enyl) (4 fluoro 3 trifluoromethylphenyl) amine(2,4 difluoro phenyl) [1(2,4 difluoro phenyl) but 3 enyl] amine(4 chloro 2 fluoro phenyl) [1(2,6 difluoro phenyl) but 3 enyl] amine(4 tert butyl phenyl) (1 cyclopropyl 3 but enyl) amine(4 tert butyl phenyl) [1(2,4 difluoro phenyl) but 3 eny] amine1[3(1 (benzothiazol 7 ylamino) but 3 enyl) indol 1 yl] ethanone4(1 thiophen 2 yl butylamino) benzonitrile[1(2 allyloxy phenyl) but 3 enyl][4(4 chloro phenoxy) phenyl] amine[1(2 fluoro 6 methoxy phenyl) but 3 enyl] (3 fluorophenyl) amine[1(2,4 diflurophenyl) but 3 enyl] (2,4,5-trifluorophenyl) amine[1(3 chloro phenyl) but enyl] (3 ethoxy phenyl) amine[4(4 chloro phenoxy) phenyl] [1(5(2 chloro phenyl) furan 2 yl) but 3 enyl] aminealdehydeallyltributylstannateamineantiinfective agentceftriaxonehalogenhomoallylic aminenaphthalene1 y (1 phenyl but 3 enyl) aminetrifluoroacetic acidunclassified drugantibacterial activityarticlecontrolled studydrug screeningdrug structuredrug synthesisin vitro studyminimum inhibitory concentrationnonhumanX ray crystallography