Malladi, S.Isloor, A.M.Peethambar, S.K.Shivananda, K.N.2026-02-052012International Journal of Pharmaceutical Research, 2012, 4, 3, pp. 81-88https://idr.nitk.ac.in/handle/123456789/26900A new series of 2,4-disubstituted thiazole derivatives were synthesized by the reaction of various 3-aryl-1H-pyrazole-4- carbaldehyde thiosemicarbazones (2a-e) and phenacyl bromides. The compounds (3a-n) were characterized by IR, NMR, mass spectra and C, H, N analyses. All the synthesized compounds were screened for their antioxidant and antimicrobial activities. Antioxidant studies revealed that, compounds 3b, 3j and 3n showed significant scavenging activity whereas compounds 3e and 3n exhibited significant antimicrobial activity. The acute oral toxicity study for the compound 3e and 3n have revealed good safety profile till the uppermost dose (2000 mg/kg).2,4 disubstituted thiazole derivative3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone3 (4 chlorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1, 3 thiazol 2 yl)hydrazone3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone3 (4 fluorophenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3 thiazol 2 yl)hydrazone3 (4 methoxyphenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone3 (phenyl) 1h pyrazole 4 carbaldehyde(4 fluorophenyl 1,3 thiazol 2 yl)hydrazone3 (phenyl) 1h pyrazole 4 carbaldehyde(4 methoxyphenyl 1,3-thiazol 2 yl)hydrazone3 (phenyl) 1h pyrazole 4 carbaldehyde(4 phenyl 1,3 thiazol 2 yl)hydrazone3 aryl 1h pyrazole 4 carbaldehyde thiosemicarbazone derivativebromine derivativebutylcresolcarbonfluconazolehydrogennitrogenphenacyl bromide derivativethiazole derivativethiosemicarbazone derivativeunclassified druganimal experimentantimicrobial activityantioxidant activityarticlecontrolled studydrug safetydrug screeningdrug synthesisfemaleinfrared spectroscopymalemass spectrometrymousenonhumannuclear magnetic resonance spectroscopy