Sankappa, Rai, U.Isloor, A.M.shetty, P.Vijesh, A.M.Prabhu, N.Isloor, S.Thiageeswaran, M.Fun, H.-K.2020-03-312020-03-312010European Journal of Medicinal Chemistry, 2010, Vol.45, 6, pp.2695-2699https://idr.nitk.ac.in/handle/123456789/12285An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials. 2010 Elsevier Masson SAS. All rights reserved.Article