Isloor, A.M.Kalluraya, B.Pai, K.2026-02-052010European Journal of Medicinal Chemistry, 2010, 45, 2, pp. 825-8302235234https://doi.org/10.1016/j.ejmech.2009.11.015https://idr.nitk.ac.in/handle/123456789/27505Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent. © 2009 Elsevier Masson SAS. All rights reserved.(n 1 aroyloxyacetyl) n 2 (3 chlorobenzo[b]thiophene 2carboxyl)hydrazine1 (3 chlorobenzo[b]thiophene 3carbonyl) 3,5 diaryl pyrazole derivative2 [3 chloro 2benzo[b]thiophenyl] 5 aryloxymethyl 1,3,4 oxadiazole3 chlorobenzo[b]thiophene 2 carboxyl chloride3 chlorobenzo[b]thiophene 2 carboxylhydrazine3 chlorobenzo[b]thiophene 2 methyl carboxylateantifungal agentantiinfective agentantiinflammatory agentbenzothiophene derivativecarrageenandiclofenacethyl 2 aryl hydrazono 3 oxobutyrategum arabicoxadiazole derivativephenazonepyrazole derivativethiadiazole derivativeunclassified druganimal experimentanimal modelantibacterial activityantifungal activityantiinflammatory activityantimicrobial activityarticlebiological activitycarbon nuclear magnetic resonancecontrolled studydrug screeningdrug structuredrug synthesisinfrared radiationinfrared spectroscopymass spectrometrynonhumanproton nuclear magnetic resonanceratAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsBacteriaDrug Evaluation, PreclinicalEdemaFungiRatsRats, WistarSpectrum AnalysisThiophenes