Poojary, M.M.Vishnumurthy, K.A.Vasudeva Adhikari, A.V.2026-02-052015Journal of Pharmaceutical Analysis, 2015, 5, 3, pp. 182-18920951779https://doi.org/10.1016/j.jpha.2015.01.002https://idr.nitk.ac.in/handle/123456789/26291Abstract The present work involves extraction of phytochemicals from the root bark of a well-known Indian traditional medicinal plant, viz. Mammea suriga, with various solvents and evaluation of their in vitro antimicrobial and antioxidant activities using standard methods. The phytochemical analysis indicates the presence of some interesting secondary metabolites like flavonoids, cardiac glycosides, alkaloids, saponins and tannins in the extracts. Also, the solvent extracts displayed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Cryptococcus neoformans with inhibition zone in a range of 20-33 mm. Further, results of their antioxidant screening revealed that aqueous extract (with IC<inf>50</inf> values of 111.51±1.03 and 31.05±0.92 ?g/mL in total reducing power assay and DPHH radical scavenging assay, respectively) and ethanolic extract (with IC<inf>50</inf> values of 128.00±1.01 and 33.25±0.89 ?g/mL in total reducing power assay and DPHH radical scavenging assay, respectively) were better antioxidants than standard ascorbic acid. Interestingly, FT-IR analysis of each extract established the presence of various biologically active functional groups in it. © 2015 Xi'an Jiaotong University.1,1 diphenyl 2 picrylhydrazylalcoholalkaloid derivativeantibiotic agentantifungal agentantioxidantcardiac glycosidedrug metaboliteflavonoidMammea suriga extractplant extractradicalsaponin derivativesolventtannin derivativeunclassified drugantibacterial activityantifungal activityantioxidant activityaqueous solutionArticleBacillus subtilisbarkcontrolled studyCryptococcus neoformansDPPH radical scavenging assaydrug isolationdrug screeningIC50in vitro studyinfrared spectroscopyinhibition zoneMammeaMammea suriganonhumanplant rootstandardStaphylococcus aureusFilobasidiella neoformans