Kiran, P.Ramakrishna, V.Trebbin, M.Udayashankar, N.K.Shashikala, H.D.2026-02-052017Journal of Advanced Research, 2017, 8, 3, pp. 279-28820901232https://doi.org/10.1016/j.jare.2017.02.001https://idr.nitk.ac.in/handle/123456789/25640In the present work, the effect of the CaO/P<inf>2</inf>O<inf>5</inf> ratio on the composition of sol-gel synthesized 58SiO<inf>2</inf>-(19 ? x)P<inf>2</inf>O<inf>5</inf>–(23 + x)CaO (x = 0, 5, 10 and 15 mol%) glass samples was studied. Further, the effect of NBO/BO ratio on hydroxy carbonated apatite layer (HCA) forming ability based on dissolution behavior in simulated body fluid (SBF) solution was also investigated. CaO/P<inf>2</inf>O<inf>5</inf> ratios of synthesized glass samples were 1.2, 2, 3.6, and 9.5, respectively. NBO/BO ratios were obtained using Raman spectroscopic analysis as 0.58, 1.20, 1.46, and 1.78, respectively. All samples were soaked in the SBF solution for 7 days. The calculated weight losses of these samples were 58%, 64%, 83%, and 89% for corresponding NBO/BO ratios. The increase in CaO/P<inf>2</inf>O<inf>5</inf> ratio increases the NBO/BO ratios. However, the increase in NBO/BO ratio increases HCA forming ability of SBF treated samples. The HCA crystalline layer formation was confirmed through X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Raman and Infrared spectroscopic analysis. Higher CaO/P<inf>2</inf>O<inf>5</inf> ratio favors the increase in HCA formation for SBF treated calcium phospho silicate glasses. © 2017Ca/P ratioDissolutionHCA layerNBO/BO ratioSBF solutionSol-gel